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N-Coumaroyldopamine & N-caffeoyldopamine
These particular compounds that are found in foods which have been consumed for hundreds of years have been shown to have incredibly potent – and selective - beta 2-adrenoceptor agonist properties in vitro...
In fact, their potency in terms of increasing cAMP is greater than that of salbutamol and rivals that of the clenbuterol, often used to, "harden", the physique by increasing muscle and decreasing fat mass (1).
It is believed to do so by activating the same signaling pathway that the powerful anabolic hormones, insulin and IGF-1, are able to activate...
In short, coumaroyldopamine & caffeoyldopamine have demonstrated the ability in vitro to increase cAMP and in turn activate Akt signaling…
Furthermore, these incredible compounds may also be able to increase muscle mass by cAMP and non-cAMP mediated mechanism (also involving Akt activation) which ultimately result in increased activation of mammalian target of rapamycin (mTOR) signaling (2,3).
Yet, another mechanism is by potentially modifying polyamine levels (androgens and GH are thought to potentially increase muscle hypertrophy by doing this), it can create yet another mechanism enabling muscle growth (5).
So, the compounds are able to activate pathways involved in the inhibition of skeletal muscle atrophy, while also being able to activate pathways involved in skeletal muscle hypertrophy. In short, it can potentially prevent muscle from being broken down, while also increasing muscle size.
But wait, just like an infomercial, that's not all...
If this weren't enough, by also increasing cAMP in fat tissue, Hormone Sensitive Lipase (HSL), which stimulates lipolysis, can be activated and lead to a reduction of fat mass.
Symplocos Racemosa Extract (standardized for triterpenoids)
This very specific extract was designed to maximize the levels of compounds which can have an additive or even synergistic effect with coumaroyldopamine & caffeoyldopamine by further enhancing their cAMP-increasing effects. It does this in part by inhibiting the degradation of cAMP...
It also goes without saying that this in turn enhances the anti-catabolic/anabolic and lipolytic effects of the coumaroyldopamine & caffeoyldopamine.
In addition, extraction for specific triterpenoid compounds is also expected to further enhance the potential ability of the formulation to increase muscle mass and decrease fat mass by enhancing skeletal muscle insulin/IGF-1 signaling, as was shown with similar compounds in animal models and in vitro (4).
Clinical studies are pending to evaluate Compound 20 and its effects upon body composition.
|Suggested Use||As a dietary supplement take 2 capsules with breakfast and 2 capsules 6-8 hours later with meal or snack. For best results, take one of the doses 30-60 minutes prior to workout.|
*Daily Value (DV) not established.
|Other Ingredients||Gelatin, Magnesium Stearate, Yellow 5, Yellow 6.|
|Warnings||This product is only intended to be consumed by healthy adults 18 years of age or older. Pregnant or nursing women should not use this product. Consult with your health care provider before using this product, especially if you are taking any prescription|
|Name||USP Labs, Compound 20 120 Capsules|
|Basic Name||Compound 20 120 Capsules|
|Serving Size||2 Capsules|
|Package Description||120 Capsules|
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