The need for a safer approach to niacin supplementation resulted in the investigation of niacin esters. One of the most widely studied of these is inositol hexaniacinate (IHN). In numerous trials it has been found to be virtually free of the side effects associated with conventional niacin therapy. Pharmacokinetic studies show the IHN molecule is absorbed intact and slowly hydrolyzed in the bloodstream, with the release of free niacin and inositol. Maximum serum levels are reached approximately 10 hours after ingestion. This allows for a more delayed release of niacin, which reduces the risk of flushing.
Extensive research has found IHN to be effective in the treatment of Raynaud’s disease and intermittent claudication. A review of the literature reveals numerous positive studies on the use of IHN in Raynaud’s disease. The typical dosage is 1 g four times daily for several months. The mechanism of action appears to be more than just a transient vasodilation, involving lipid lowering and fibrinolysis. This explains the need for long-term administration. The use of inositol hexaniacinate for the treatment of intermittent claudication secondary to atherosclerosis has been examined extensively. Significant improvement has been reported by several investigators at dosages of 2 g twice daily, typically for at least three months. While arterial dilation may be a factor, it has been postulated that reduction in fibrinogen, improvement in blood viscosity, and resultant improvement in oxygen transport are involved in the therapeutic effects. IHN appears to have application in the treatment of other conditions resulting from peripheral vascular insufficiency, including restless legs syndrome, stasis dermatitis, atherosclerosis related migraines, and hypertension.
|Supplement Facts||Dosage:1 to 3 capsules tid
A woman who is pregnant or nursing, or who might become pregnant, should consult a health-care practitioner before using this product.
SPECIAL NOTE: Use of high-dose niacin is contraindicated in patients with gout.
|Name||Thorne Research, Niasafe-600 60 capsules|
|Product Type||Corn Free, Dairy Free, Egg Free, Gluten Free, Hypoallergenic, Wheat Free, Yeast Free|