Thorne Research, Calcium D-Glucarate 90 capsules

SKU: TR-M280

Availability: Out of stock


Quick Overview

    Product Description

    Calcium D-glucarate is the calcium salt of D-glucaric acid, a substance produced naturally in small amounts by humans. Oral supplementation of calcium D-glucarate has been shown to inhibit beta-glucuronidase, preventing recycling of hormones and carcinogenic toxins, allowing for
    adequate phase II detoxification and excretion.

    Glucuronidation is the process of attaching a glucuronic acid molecule to substances for detoxification and elimination from the body. During phase II detoxification, chemical carcinogens, steroid hormones, and other lipidsoluble toxins undergo glucuronidation and are then excreted through
    the bile or urine. However, the enzyme beta-glucuronidase is capable of deconjugating these hormones, toxins, and carcinogens, thereby making it possible for them to be reabsorbed rather than excreted. Elevated betaglucuronidase activity is associated with increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers.

    The metabolites produced from calcium D-glucarate have been shown to inhibit beta-glucuronidase activity, increasing excretion of conjugated xenobiotic compounds and decreasing activity of harmful substances that are most active in their deconjugated state. Upon ingestion and
    exposure to the acidic environment of the stomach, calcium D-glucarate is metabolized to form D-glucaric acid. D-glucaric acid is further metabolized in the gastrointestinal tract into three compounds existing in equilibrium and comprised of approximately 40-percent D-glucaric acid, 30 percent D-glucaro-1,4-lactone, and 30-percent D-glucaro-6,3-lactone. These compounds are then transported to the blood and various internal organs, and are subsequently excreted in the urine and bile. Calcium D-glucarate administration results in inhibition of beta-glucuronidase activity for approximately five hours with each dosing.

    Clinical applications of oral calcium D-glucarate include lipid lowering and support for healthy hormone metabolism, particularly in excess-estrogen conditions such as hormone-dependent cancers, polycystic ovaries, endometriosis, and PMS. Animal studies have also demonstrated inhibition of cancer types not usually considered hormone related, including skin, colon, liver, and lung cancers.

    Supplement Facts

    Supplement Facts

    Dosage:1 to 2 capsules tid

    Each Capsule Contains   DV%
    Calcium D-Glucarate 500 mg *
    *Daily Value (DV) not established    
    M280/ 90


    A woman who is pregnant or nursing, or who might become pregnant, should consult a health-care practitioner before using this product.


    SPECIAL NOTE: Calcium D-Glucarate is not considered to be a calcium supplement, although each capsule does contain 81 mg calcium.

    Additional Information

    SKU TR-M280
    Name Thorne Research, Calcium D-Glucarate 90 capsules
    UPC 693749280026
    MPN M280
    Brand Thorne Research
    Form Capsule
    Shipping Weight 0.1700
    Serving Size 1
    Product Type Corn Free, Dairy Free, Egg Free, Gluten Free, Hypoallergenic, Wheat Free, Yeast Free


    5 Stars

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    The most helpful favorable review

    Based on the researech I've done Calcium D-Glucarate is a very important addition to my daily vitamin intake. I never let myself run out as it is one of the most critical vitamins of the day.

    Published by Florida George on 2011-09-27 17:24:08
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    The most helpful critical review
    • Great Product/Great Price!

      Posted by Bobbi on March 20, 2012
      I had purchased this item for years from a local store and much prefer the service (delivered to my home) and price of!!
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    • Excellent Product & Price!

      Posted by chrissy on August 15, 2011
      Very pleased with this product--so glad I found your website. I will continue to order from you. Thanks.
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    • Removes the bad Estrogen

      Posted by Mo on March 5, 2012
      Love this product for keeping the bad estrogen eliminated from the body, hormones are balanced and breast tenderness minimized.
      Was this review helpful to you?
    • Excellent Product

      Posted by Joanie in NC on July 16, 2011
      I love everything from Thorne. My natropatic doctor recommended this and I am very pleased.
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    • Great Product

      Posted by Suzanne on April 26, 2010
      Great product, great price, very quick shipping
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    • thumbs up!

      Posted by Jan on November 24, 2010
      best price on Calc D-Glucarate I could find!!
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