- Dietary Supplement
Folic acid must be converted to its active forms to be used by the body. This is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not occur sufficiently enough to meet the body’s needs. Furthermore, up to one-third of the U.S. population may have a genetic enzyme defect that makes it difficult for them to convert folic acid (even folinic acid) into active 5-MTHF. For these individuals and many others, 5-MTHF supplementation may be a more effective method of folate repletion.
Because deficiencies of folic acid have been linked to low-birth-weight infants and neural tube defects, folic acid requirements double during pregnancy. The Centers for Disease Control and Prevention recommends folic acid supplementation for all women of childbearing age because the
biggest need is during the first trimester, when a woman may not even be aware she is pregnant. Women predisposed to having a child with a neural tube defect may have an abnormality in the ability to convert folic acid to the more active 5-MTHF. Supplementation with the more active form may be preferable.
In concert with vitamin B12, 5-MTHF functions as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine. Methyl-group donation is vital to many biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA. Certain
neurological, cognitive, and psychiatric conditions, including depression, peripheral neuropathy, myelopathy, restless legs syndrome, insomnia, forgetfulness, irritability, dementia, endogenous depression, organic psychosis, and schizophrenia-like syndromes may be secondary to folate
Depression is associated with lower serum and RBC folate concentrations, and a folate deficiency predicts a poorer response to some antidepressant medications. Several studies have documented improvement in depression in patients subsequent to oral supplementation with folate at doses of 5-50 mg daily. Folic acid (500 mcg per day) significantly improved the antidepressant action of fluoxetine in subjects with major depression.
|Suggested Use||1-3 capsules daily.|
*Daily Value (DV) not established.
|Warnings||A woman who is pregnant or nursing, or who might become pregnant, should consult a health care practitioner before using this product.|
|Name||Thorne Research, 5-MTHF 60 Vegetarian Capsules|
|Serving Size||1 Vegetarian Capsule|
|Package Description||60 Vegetarian Capsules|
|Product Type||Corn Free, Dairy Free, Egg Free, Gluten Free, Hypoallergenic, Wheat Free, Yeast Free|
I was originally prescribed this product by my Applied Kinesiology Chiropractor, who used muscle testing to determine that I needed this form of Folic Acid because my body was not absorbing/utilizing other forms. It has significantly enhanced my energy level. Excellent price, too!
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I can tell a difference in my energy and endurance if I miss even 3 days of this product.
This is a safe product without trash fillers....I love it!Was this review helpful to you?
it's really goodIt's a really good product. My Doctor Prescribed Deplin for my Husband and I because our bodies do not absorb Folic acid, I asked if there was a natural alternative and she recommended this product. I felt the difference right away.Was this review helpful to you?
greatI am glad that i found this for my son. i am very happy with the free shipping. i will be ordering it monthly or so.Was this review helpful to you?
good folinic!This product is needed, if ever take vitamin
Methyl B12 (drops). This is the correct form folinik that
avoids hyperactive autistic childWas this review helpful to you?
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