Grapenol

Grapenol® tablets, provided by Douglas Laboratories®, contain 100% pure, full-spectrum grape extract. Each 50 mg scored tablet is formulated to disintegrate rapidly within several minutes after ingestion for maximum bioavailability. This highly concentrated red grape extract (Vitis vinifera) is specially prepared to retain the natural antioxidant and biological activity of various nutritional compounds occurring in the grape seeds, skin, and stems. Using the whole grape, not just the seeds, yields a broader array of antioxidant benefits, including those of resveratrol, a powerful free radical fighter.

Proanthocyanidins (also called leukoanthocyanidins) are a class of natural polyphenolic bioflavonoids that are very widespread in nature. They are found in many herbs, fruits and vegetables, and often are the main precursors of the blue-violet and red pigments. More than 90% of the proanthocyanidins in Grapenol occur as chains of two, three or more proanthocyanidin molecules, which are called oligomeric proanthocyanidins (OPC). These OPC are considered most potent for their health benefits. Only a small fraction of Grapenol proanthocyanidins are present as single molecules (monomers, like catechin and epi-catechin).

FUNCTIONS
Proanthocyanidins are highly regarded for their strong antioxidant properties, and for their functions in supporting the body’s connective tissues and capillary blood vessel system.
Europeans have been studying and using various forms of these natural proanthocyanidins for several decades for their numerous beneficial effects. Proanthocyanidins are among the most powerful natural free-radical scavengers yet discovered. As such, proanthocyanidins have their own unique place in the body’s overall protection against harmful free
radical damage. Proanthocyanidins appear to be especially effective in neutralizing highly reactive hydroxyl and singlet oxygen radicals. Both of these reactive oxygen species are involved in the regulation of normal inflammatory processes. Grapenol enhances the effectiveness of vitamins C and E and can be taken together with these vitamins for added
benefit.

Proanthocyanidins also support and enhance the activity of vitamin C, and are known for their ability to help support the health of the body's capillary system and connective tissues. Proanthocyanidins have been shown to bind with collagen fibers, thereby protecting them from premature degradation. This helps maintain the natural elasticity of collagen
in skin, joints, arteries, capillaries, and other connective tissues. In addition to proanthocyanidins, Grapenol also contains gallic acid and gallic acid esters, compounds
that are known for their astringent and antioxidant (gallic acid esters) properties.

INDICATIONS
Grapenol tablets may be a useful nutritional adjunct for individuals who wish to increase their intake of natural antioxidants in the bioflavonoid family of nutrients. Grapenol can be helpful in extending the benefits of vitamin C and other dietary antioxidants. Bioflavonoids are unable to be synthesized in the body and must be obtained through dietary intake.
The flavonoids in Grapenol are readily available and well-absorbed substances.

SUGGESTED USE
The amount of Grapenol usually taken is based on body weight as larger individuals can use more. Initial amounts for the first 7 to 10 days range from 1.5 to 3.0 milligrams per kilogram (2.2 pounds) of body weight, followed by maintenance amounts of 50 to 100 mg per day (1 or 2 tablets) to replace what is lost daily.

SIDE EFFECTS
No adverse effects have been reported.

STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.