Glucosamine Plus Extra Strength

Glucosamine Plus Extra Strength capsules, provided by Douglas Laboratories®, contain a synergistic combination of glucosamine sulfate and chondroitin sulfate. Glucosamine sulfate is a well-absorbed source of glucosamine, an important precursor for the synthesis and maintenance of connective tissues. Chondroitin sulfate also supports formation of connective tissues, primarily joint cartilage, and helps protect existing cartilage. The potassium stabilized form of glucosamine sulfate is used, making these sodium-free products.

FUNCTIONS
Glucosamine is a naturally occurring amino sugar found ubiquitously in glycoproteins and glycosaminoglycans. Glycosaminoglycans, formerly named mucopolysaccharides, are an integral component of all connective tissues. Connective tissue, a fibrous type of body tissue, has various functions. It supports and connects internal organs (ligaments), forms bone, cartilage, and the walls of blood vessels, attaches muscles to bones (tendons), and replaces tissues that have been damaged following injury. The two main components of connective tissue are collagen
and proteoglycans.

Collagen is the strong, fibrous protein that physically connects our tissues. Proteoglycans are large carbohydrate-rich structures, resembling a bottlebrush in three-dimensional structure, i.e., a central protein rod with many strings of glucosamine-containing glycosaminoglycans  extending outwards. Proteoglycans hold large amounts of water forming a stiff gel by virtue of their dense negative charges from sulfates. Proteoglycans are linked to collagen fibers to help form connective tissues, and proteoglycans provide resiliency, load distribution, shock-absorbing, compressive and lubricating properties to connective tissues and joints.

Glycosaminoglycans and proteoglycans are continuously being formed and replaced in connective tissues. Remodeling of connective tissues is also continuous, albeit slowly, with turnover half-lives of almost two years in healthy human joints. Turnover is accelerated in wound healing, arthritic joints, and burns. New synthesis of glycosaminoglycans has clinical importance in skin during normal wound healing, in bone during fracture repair and osteoporosis, and in joints. In these instances, glycosaminoglycan synthesis is necessary for healing, and enhancement of glycosaminoglycan and proteoglycan deposition may improve tissue repair. Glycosaminoglycans are synthesized primarily by fibroblasts (skin, tendons, ligaments), osteoblasts (bone), and chondrocytes (cartilage).

Thus, the cell’s ability to manufacture glycosaminoglycans and secrete proteoglycans is crucial during any healing or joint disease process. The availability of glucosamine is the key, rate-limiting step in glycosaminoglycan and proteoglycan synthesis in all connective tissues, such as skin, bone, cartilage, tendons, and ligaments. Only with sufficient glucosamine, the synthesis can proceed.

INDICATIONS
Glucosamine Plus Extra Strength capsules may be a useful nutritional adjunct for individuals who wish to support the body’s connective tissues, such as skin, tendons, ligaments, bone, and cartilage.

SUGGESTED USE
Glucosamine Plus Extra Strength: One to three capsules daily. It is recommended that Glucosamine Plus and Glucosamine Plus Extra Strength be taken with meals.

SIDE EFFECTS
No adverse effects have been reported.

STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.