EstroFlavone

EstroFlavone™ capsules, provided by Douglas Laboratories®, contain hesperidin methyl chalcone, concentrated soy isoflavones, and black cohosh root and rhizome extract, standardized to contain a minimum of 2.5% triterpenes.

FUNCTIONS
Hesperidin Methyl Chalcone: Hesperidin methyl chalcone is a methylated derivative of the flavonoid hesperidin. Hesperidin methylchalcone supports and protects the integrity of the vascular system with particular activity in the capillaries and veins. Hesperidin methylchalcone has been shown to help strengthen capillaries by increasing capillary resistance and decreasing capillary permeability. Increased venous motility, tone, and the ability of vessels to dilate are also enhanced by hesperidin methylchalcone. Soy Isoflavone Concentrate: Isoflavones are a class of phytoestrogens — plant-derived compounds that are similar in structure and/or function to animal estrogens.
In plants, isoflavones are bound to glycosides. During digestion, colonic bacteria are thought to metabolize the inactive isoflavone glycosides into their active counterparts. Soybeans and soy products are the most well-known
and significant dietary sources of isoflavones. Genistein and daidzein, two of the predominant isoflavones that are beneficial to health, are present in significant concentrations in soy foods.

Epidemiological studies have found that individuals with high soy intakes often enjoy certain health advantages. Numerous laboratory and clinical studies have investigated the health benefits of soy, many of which have identified soy isoflavones as key components responsible for the health benefits associated with soy foods. Isoflavones have both weak estrogenic and antiestrogenic activity, which may contribute to their ability to moderate menopausal symptoms and support maintenance of bone mineral density. Isoflavones also help protect the cardiovascular system, support the immune system, inhibit angiogenesis, and protect against oxidative damage as antioxidants.

Black Cohosh: Black cohosh extract is quickly gaining popularity as a natural way to moderate and balance hormone levels. The active constituents of black cohosh appear to regulate estrogen levels, thereby normalizing
hormonal balance and moderating the symptoms that accompany fluctuating hormone levels. Black cohosh extract works largely through the synergistic activity of two types of compounds: phytoestrogens and triterpenes. Phytoestrogens, a class of flavonoids with mild estrogenic activity in the body, appear to have normalizing effects on hormonal levels. In particular, black cohosh extract contains formononetin, an isoflavone phytoestrogen.

Triterpene glycosides found in black cohosh extract act synergistically with formononetin to suppress excessive secretion of luteinizing hormone (LH). Sudden increases in LH secretion, which occur in response to declining estrogen levels, appear largely responsible for many symptoms associated with menopause, such as hot flashes, night sweats, insomnia, irritability, heart palpitations, and headaches. Additionally, the concerted activity of formononetin and triterpenes appears to aid in the regulation of estrogen balance. As with other estrogenic compounds, the active constituents in black cohosh extract may have beneficial effects in the cardiovascular and skeletal systems of postmenopausal women. As such, black cohosh offers a safe and natural method of balancing fluctuating hormone levels and easing the resulting symptoms that can occur during menopause.

INDICATIONS
EstroFlavone™ may be a beneficial component of the nutritional support program of women who wish to assist hormone balance and support the health of blood vessels and capillaries during menopause.

SUGGESTED USE
1 to 2 capsules daily with meals or as directed by physician. It is recommended that prolonged use of black cohosh beyond six months be under physician supervision.

SIDE EFFECTS
No adverse effects have been reported.

STORAGE
Store in a cool, dry place, away from direct light. Keep out of reach of children.