Douglas Labs, Glucosamine Plus 120 Vegetarian Capsules

From: Douglas Labs

Availability: Out of stock


Quick Overview

    • Dietary Supplement

    • Joint/Connective Tissue Function

Product Description

Glucosamine Plus, provided by Douglas Laboratories, contains a synergistic combination of glucosamine sulfate and chondroitin sulfate. Glucosamine sulfate is a well-absorbed source of glucosamine, an important precursor for the synthesis and maintenance of connective tissues. Chondroitin sulfate also supports formation of connective tissues, primarily joint cartilage, and helps protect existing cartilage. The potassium stabilized form of glucosamine sulfate is used, making these sodiumfree products.

Glucosamine is a naturally occurring amino sugar found ubiquitously in glycoproteins and glycosaminoglycans. Glycosaminoglycans, formerly named mucopolysaccharides, are an integral component of all connective tissues.

Connective tissue, a fibrous type of body tissue, has various functions. It supports and connects internal organs (ligaments), forms bone, cartilage, and the walls of blood vessels, attaches muscles to bones (tendons), and replaces tissues that have been damaged following injury. The two main components of connective tissue are collagen and proteoglycans. Collagen is the strong, fibrous protein that physically connects our tissues. Proteoglycans are large carbohydrate-rich structures, resembling a bottlebrush in three-dimensional structure, i.e., a central protein rod with many strings of glucosamine-containing glycosaminogly-cans extending outwards. Proteoglycans hold large amounts of water forming a stiff gel by virtue of their dense negative charges from sulfates. Proteoglycans are linked to collagen fibers to help form connective tissues, and proteoglycans provide resiliency, load distribution, shockabsorbing, compressive and lubricating properties to connective tissues and joints.

Glycosaminoglycans and proteoglycans are continuously being formed and replaced in connective tissues. Remodeling of connective tissues is also continuous, albeit slowly, with turnover half-lives of almost two years in healthy human joints. Turnover is accelerated in wound healing, arthritic joints, and burns. New synthesis of glycosaminoglycans has clinical importance in skin during normal wound healing, in bone during fracture repair and osteoporosis, and in joints. In these instances, glycosaminoglycan synthesis is necessary for healing, and enhancement of glycosaminoglycan and proteoglycan deposition may improve tissue repair.

Glycosaminoglycans are synthesized primarily by fibroblasts (skin, tendons, ligaments), osteoblasts (bone), and chondrocytes (cartilage). Thus, the cell’s ability to manufacture glycosaminoglycans and secrete proteoglycans is crucial during any healing or joint disease process.

The availability of glucosamine is the key, rate-limiting step in glycosaminoglycan and proteoglycan synthesis in all connective tissues, such as skin, bone, cartilage, tendons, and ligaments. Only with sufficient glucosamine, the synthesis can proceed.

The body has a long metabolic pathway to synthesize a glucosamine derivative, UDP-N-acetylglucosamine, which is used for glycosaminoglycan synthesis. In addition, exogenous, i.e., dietary, glucosamine serves as an immediate precursor for glycosaminoglycan synthesis, and also stimulates incorporation of other precursors into the connective tissue matrix.

Chondroitin sulfate, a glycosaminoglycan formed in the body, is also used for the synthesis and maintenance of connective tissue, primarily within the cartilage matrix. In addition, chondroitin sulfate protects existing cartilage by reducing water loss from the matrix and by inhibiting the enzymatic breakdown of the cartilage.

The overlapping activities as well as functional differences of glucosamine and chondroitin sulfate offer several advantages for combined supplementation. Although glucosamine is a precursor for chondroitin synthesis, this process requires large amounts of metabolic en

Supplement Facts

Suggested Use

One capsule three times daily or as directed by a physician.

Supplement Facts
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Servings Per Container: 120
  Amount Per Serving % DV
Glucosamine Sulfate.2KCl (from crab and shrimp)  250 mg 
Chondroitin Sulfate 200 mg *

*Daily Value (DV) not established.

Other Ingredients

Cellulose, vegetable stearate, and silica.

Warnings If you have aan allergy to shelfish you should not use this product.

Additional Information

Name Douglas Labs, Glucosamine Plus 120 Vegetarian Capsules
UPC 745287200216
Brand Douglas Labs
Form Vegetarian Capsule
Shipping Weight 0.2500
Serving Size 1 Vegetarian Capsule
Package Description 120 Vegetarian Capsules
Product Type Vegetarian


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