Coenzyme Q10 is a small, organic molecule intimately involved with energy utilization in the mitochondria – the biosynthesis of ATP, GTP and UTP from foods. CoQ10 is not readily available in significant amounts from most sources and should be supplemented to maintain adult health.
- A potent antioxidant; helps maintain healthy mitochondrial and lysosomal levels of CoQ10
- An anti-aging nutritional. Regular supplementation with large, therapeutic doses of Co Q10 has been documented to slow the progression of Parkinson’s disease
- Helps offset the decline of CoQ10 levels for those individuals taking HMG-CoA reductase inhibitors2 (prescription medications [statins] to reduce serum cholesterol levels)
- Helps avoid the pro-inflammatory state by limiting ceramide3 release from membranes under oxidative stress – ceramides initiate activation of caspases (proteolytic enzymes) leading to cell death (apoptosis)
- Large amounts (300 mg/day) may be therapeutic for relief of migraine attacks
Coenzyme Q10, also known as ubiquinone, is a fat-soluble, water insoluble coenzyme normally synthesized in the body in small quantities. This coenzyme is absolutely required for the proper function of mitochondria and lysosomes; these are subcellular organelles, partitions, within every living cell. CoQ10 is an integral component of the electron transport chain within mitochondria, gathering reducing power from several enzymes of the fatty acid and Krebs cycles and passing this reducing power to important cytochromes of the electron transport pathway. This eventually ends with reduction of atmospheric oxygen to water and the biosynthesis of ATP from ADP and phosphate (which is why we breathe). As humans age, the amount of CoQ10 synthesized by cells decreases dramatically and the decline affects all organs of the body. It is wise to begin supplementation of this nutrient well before old age to keep a large number of viable mitochondria and lysosomes in each cell.
Because CoQ10 plays a central role in the production of ATP, supplementation with CoQ10 has been shown beneficial for heart health and skeletal muscle health. Muscle samples from aged patients before and after hip surgery displayed significant improvement in the fiber type composition – towards younger type muscles - for those on CoQ10. In a 6 year study of 500 patients with histories of CVD, 250 taking statin drugs and 250 controls, those taking the statin drug exhibited both reduced plasma cholesterol and lower CoQ10 concentrations8. The results were not surprising but importantly, the investigators also found this significant drop of plasma CoQ10 did not encourage more cardiovascular problems within the statin group, who did better than the control group (those not taking medication). Another study followed two matched groups of patients who had all suffered acute myocardial infarctions; results demonstrated the numbers of serious events, including death, were reduced significantly in the group taking 120 mg CoQ10/day. We can reconcile these superficial conflicts by suggesting while statin drugs are beneficial, the combination of CoQ10 along with statin therapy is even better for those with CVD. This is also consistent with studies of myopathy for those taking statin drugs where some patients complain of skeletal muscle aches and pains – a possible effect of low CoQ10 levels in muscles. Patients with well-developed atherosclerosis exhibited much less fatigue when taking CoQ10 than not. Clinicians might be advised to inquire if the patient is currently taking statins if unexplained lower back, hip or leg pains persist despite therapy. Symptoms often respond to CoQ10 and/or vitamin D3 supplementation.
A recently discovered, exciting benefit of CoQ10 supplementation has been report
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|Name||Anabolic Laboratories, Coenzyme Q10 100 mg 60 capsules|
|Package Description||60 Softgels|